Laboratory for Selective Synthesis
and Catalysis at UVic
Publications
27.
Manuscript in preparation
26.
Palladium (II)-Catalyzed C–H Activation with Bifunctional Ligands: From Curiosity to Industrialization
K. Wu*, N. Y. S. Lam*, D. A. Strassfeld, Z. Fan, J. X. Qiao, T. Liu, D. Stamos, J.-Q. Yu
Pre 2024
25. Ortho-Selective amination of arene carboxylic acids via rearrangement of acyl O-hydroxylamines
J. E. Gillespie, N. Y. S. Lam, R. J. Phipps
Chem. Sci. 2023, 14, 10103-10111
24. Molecular editing of aza-arene C–H bonds by distance, geometry and chirality
Z. Fan, X. Chen, K. Tanaka, H. S. Park, N. Y. S. Lam, J. J. Wong, K. N. Houk, J. Q. Yu
23. An enantioselective Suzuki–Miyaura coupling to form axially chiral biphenols
R. Pearce-Higgins, L. N Hogenhout, P. J. Docherty, D. M Whalley, P. Chuentragool, N. Lee, N. Y. S. Lam, T. M. McGuire, D. Valette, R. J. Phipps
J. Am. Chem. Soc. 2022,144, 15026-15032
22. Deep‐Sea Discovery and Detective Work: Towards Solving the Hemicalide Structural Enigma through Computational NMR Analysis and Stereocontrolled Synthesis
N. Y. S. Lam*, I. Paterson*
Eur. J. Org. Chem. 2022, 25, e202200467
21. A Solid Support‐Based Synthetic Strategy for the Site‐Selective Functionalization of Peptides with Organometallic Half‐Sandwich Moieties
D. Truong, N. Y. S. Lam, M. Kamalov, M. Riisom, S. M. F. Jamieson, P. W. R. Harris, M. A. Brimble, N. Metzler‐Nolte, C. G. Hartinger
Chem. Eur. J. 2022, 28, e202104049
20. Empirical guidelines for the development of remote directing templates through quantitative and experimental analyses
N. Y. S. Lam, Z. Fan, K. Wu, H. S. Park, S. Y. Shim, D. A. Strassfeld, J. Q. Yu
J. Am. Chem. Soc. 2022,144, 2793-2803
19. Palladium-Catalyzed Enantioselective β-C(sp3)–H Activation Reactions of Aliphatic Acids: A Retrosynthetic Surrogate for Enolate Alkylation and Conjugate Addition
E. L. Lucas, N. Y. S. Lam, Z. Zhuang, H. S. S. Chan, D. A. Strassfeld, J. Q. Yu
Acc. Chem. Res. 2022, 55, 537-550
18. A synthesis-enabled relative configurational assignment of the C31–C46 region of hemicalide
T. P. Stockdale, N. Y. S. Lam*, I, Paterson*
Chem. Commun. 2022, 58, 5729-5732
17. A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation
T. Zhang, Y. X. Luan, N. Y. S. Lam, J. F. Li, Y. Li, M. Ye, J. Q. Yu
16. Mechanistic Study of Enantioselective Pd-Catalyzed C(sp3)–H Activation of Thioethers Involving Two Distinct Stereomodels
T. G. Saint-Denis, N. Y. S. Lam, N. Chekshin, P. F. Richardson, J. S. Chen, J. Elleraas, K. D. Hesp, D. C. Schmitt, Y. Lian, C. W. Huh, J. Q. Yu
15. Advancing the logic of chemical synthesis: C−H activation as strategic and tactical disconnections for C−C bond construction
N. Y. S. Lam, K. Wu, J. Q. Yu
Angew. Chem. Int. Ed. 2021,133, 15901-15924
14. The stereocontrolled total synthesis of polyketide natural products: a thirty-year journey
T. P. Stockdale*, N. Y. S. Lam*, M. J. Anketell, I. Paterson
Bull. J. Chem. Soc. Jpn. 2021, 94, 713-731
13. Conquering peaks and illuminating depths: developing stereocontrolled organic reactions to unlock nature's macrolide treasure trove
N. Y. S. Lam, T. P. Stockdale, M. J. Anketell, I Paterson
Chem. Commun. 2021, 57 , 3171-3189
12. Achieving site-selectivity for C–H activation processes based on distance and geometry: a carpenter’s approach
G. Meng*, N. Y. S. Lam*, E. L. Lucas*, T. G. Saint-Denis, P. Verma, N. Chekshin, J. Q. Yu
J. Am. Chem. Soc. 2020,142 , 10571-10591
11. Stereocontrolled synthesis as an enabling tool for the configurational assignment of marine polyketide natural products
N. Y. S. Lam, I. Paterson
Eur. J. Org. Chem. 2020,16, 2310-2320
10. Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A
I. E. Ndukwe, X. Wang, N. Y. S. Lam, K. Ermanis, K. L. Alexander, M. J. Bertin, G. E. Martin, G. Muir, I. Paterson, R. Britton, J. M. Goodman, E. J. N. Helfrich, J. Piel, W. H. Gerwick, R. T. Williamson
Chem. Commun. 2020, 56, 7565-7568
9. Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
T. R. Pettigrew, R. J. Porter, S. J. Walsh, M. P. Housden, N. Y. S. Lam, J. S. Carroll, J. S. Parker, D. R Spring, I. Paterson
Chem. Commun. 2020, 56 , 1529-1532
8. A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A
N. Y. S. Lam, G. Muir, V. R. Challa, R. Britton, I. Paterson
Chem. Commun. 2020 55, 9717-9720
7. From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents
N. Y. S. Lam, D. Truong, H. Burmeister, M. V. Babak, H. U. Holtkamp, S. Movassaghi, D. M. Ayine-Tora, A. Zafar, M. Kubanik, L. Oehninger, T. Söhnel, J. Reynisson, S. M. F. Jamieson, C. Gaiddon, I. Ott, C. G. Hartinger
Inorg. Chem. 2018, 57, 14427-14434
6. Analysis of ruthenium anticancer agents by MEEKC‐UV and MEEKC–ICP‐MS: Impact of structural motifs on lipophilicity and biological activity
K. Giringer, H. U. Holtkamp, S. Movassaghi, W. D. J. Tremlett, N. Y. S. Lam, M. Kubanik, C. G. Hartinger
Electrophoresis 2018 39, 1201-1207
5. Challenges and discoveries in the total synthesis of complex polyketide natural products
I. Paterson*, N. Y. S. Lam*
J. Antibiot. 2018, 71, 215-233
4. Toward the total synthesis of patellazole B: synthesis of an advanced C1–C25 fragment corresponding to the macrocyclic skeleton
A. W. Phillips, M. J. Anketell, T. Balan, N. Y. S. Lam, S. Williams, I Paterson
Org. Biomol. Chem. 2018,16, 8286-8291
3. Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein–Ru (carbene) adduct
M. P Sullivan, M. K. Nieuwoudt, G. A. Bowmaker, N. Y. S. Lam, D. Truong, D. C. Goldstone, C. G. Hartinger
Chem. Commun. 2018, 54, 6120-6123
2. A synthesis-enabled relative stereochemical assignment of the C1–C28 region of hemicalide
B. Y. Han*, N. Y. S. Lam*, C. I. MacGregor, J. M. Goodman, I. Paterson
Chem. Commun. 2018, 54, 3247-3250
1. Quinoline-para-quinones and metals: coordination-assisted formation of quinoline-ortho-quinones
M. Kubanik, N. Y. S. Lam, H. U. Holtkamp, T. Söhnel, R. F. Anderson, S. M. F. Jamieson, C. G. Hartinger