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Palladium (II)-Catalyzed C–H Activation with Bifunctional Ligands: From Curiosity to Industrialization

K. Wu*, N. Y. S. Lam*, D. A. Strassfeld, Z. Fan, J. X. Qiao, T. Liu, D. Stamos, J.-Q. Yu

Angew. Chem. Int. Ed. 2024 e202400509

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Pre 2024

25. Ortho-Selective amination of arene carboxylic acids via rearrangement of acyl O-hydroxylamines

J. E. Gillespie, N. Y. S. Lam, R. J. Phipps

Chem. Sci. 2023, 14, 10103-10111

24. Molecular editing of aza-arene C–H bonds by distance, geometry and chirality

Z. Fan, X. Chen, K. Tanaka, H. S. Park, N. Y. S. Lam, J. J. Wong, K. N. Houk, J. Q. Yu

Nature 2022, 610, 87-93


23. An enantioselective Suzuki–Miyaura coupling to form axially chiral biphenols

​R. Pearce-Higgins, L. N Hogenhout, P. J. Docherty, D. M Whalley, P. Chuentragool, N. Lee, N. Y. S. Lam, T. M. McGuire, D. Valette, R. J. Phipps
J. Am. Chem. Soc. 2022,144, 15026-15032

22. Deep‐Sea Discovery and Detective Work: Towards Solving the Hemicalide Structural Enigma through Computational NMR Analysis and Stereocontrolled Synthesis

N. Y. S. Lam*, I. Paterson*

Eur. J. Org. Chem. 2022, 25, e202200467

21. A Solid Support‐Based Synthetic Strategy for the Site‐Selective Functionalization of Peptides with Organometallic Half‐Sandwich Moieties

D. Truong, N. Y. S. Lam, M. Kamalov, M. Riisom, S. M. F. Jamieson, P. W. R. Harris, M. A. Brimble, N. Metzler‐Nolte, C. G. Hartinger

Chem. Eur. J. 2022, 28, e202104049

20. Empirical guidelines for the development of remote directing templates through quantitative and experimental analyses

N. Y. S. Lam, Z. Fan, K. Wu, H. S. Park, S. Y. Shim, D. A. Strassfeld, J. Q. Yu

J. Am. Chem. Soc.  2022,144, 2793-2803

19. Palladium-Catalyzed Enantioselective β-C(sp3)–H Activation Reactions of Aliphatic Acids: A Retrosynthetic Surrogate for Enolate Alkylation and Conjugate Addition

E. L. Lucas, N. Y. S. Lam, Z. Zhuang, H. S. S. Chan, D. A. Strassfeld, J. Q. Yu

Acc. Chem. Res. 2022, 55, 537-550

18. A synthesis-enabled relative configurational assignment of the C31–C46 region of hemicalide

T. P. Stockdale, N. Y. S. Lam*, I, Paterson*

Chem. Commun. 2022, 58, 5729-5732

17. A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation

T. Zhang, Y. X. Luan, N. Y. S. Lam, J. F. Li, Y. Li, M. Ye, J. Q. Yu

Nat. Chem. 2021,13, 1207-1213

16. Mechanistic Study of Enantioselective Pd-Catalyzed C(sp3)–H Activation of Thioethers Involving Two Distinct Stereomodels

T. G. Saint-Denis, N. Y. S. Lam, N. Chekshin, P. F. Richardson, J. S. Chen, J. Elleraas, K. D. Hesp, D. C. Schmitt, Y. Lian, C. W. Huh, J. Q. Yu

ACS Catal. 2021,11, 9738-9753

15. Advancing the logic of chemical synthesis: C−H activation as strategic and tactical disconnections for C−C bond construction

N. Y. S. Lam, K. Wu, J. Q. Yu

Angew. Chem. Int. Ed.  2021,133, 15901-15924

14. The stereocontrolled total synthesis of polyketide natural products: a thirty-year journey

T. P. Stockdale*, N. Y. S. Lam*, M. J. Anketell, I. Paterson

Bull. J. Chem. Soc. Jpn. 2021, 94, 713-731

13. Conquering peaks and illuminating depths: developing stereocontrolled organic reactions to unlock nature's macrolide treasure trove

N. Y. S. Lam, T. P. Stockdale, M. J. Anketell, I Paterson

Chem. Commun. 2021, 57 , 3171-3189

12. Achieving site-selectivity for C–H activation processes based on distance and geometry: a carpenter’s approach

G. Meng*, N. Y. S. Lam*, E. L. Lucas*, T. G. Saint-Denis, P. Verma, N. Chekshin, J. Q. Yu

J. Am. Chem. Soc. 2020,142 , 10571-10591

11. Stereocontrolled synthesis as an enabling tool for the configurational assignment of marine polyketide natural products

N. Y. S. Lam, I. Paterson

Eur. J. Org. Chem. 2020,16, 2310-2320

10. Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A

I. E. Ndukwe, X. Wang, N. Y. S. Lam, K. Ermanis, K. L. Alexander, M. J. Bertin, G. E. Martin, G. Muir, I. Paterson, R. Britton, J. M. Goodman, E. J. N. Helfrich, J. Piel, W. H. Gerwick, R. T. Williamson

Chem. Commun. 2020, 56, 7565-7568

9. Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents

T. R. Pettigrew, R. J. Porter, S. J. Walsh, M. P. Housden, N. Y. S. Lam, J. S. Carroll, J. S. Parker, D. R Spring, I. Paterson

Chem. Commun. 202056 , 1529-1532

8. A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A

N. Y. S. Lam, G. Muir, V. R. Challa, R. Britton, I. Paterson

Chem. Commun. 2020 55, 9717-9720

7. From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents

N. Y. S. Lam, D. Truong, H. Burmeister, M. V. Babak, H. U. Holtkamp, S. Movassaghi, D. M. Ayine-Tora, A. Zafar, M. Kubanik, L. Oehninger, T. Söhnel, J. Reynisson, S. M. F. Jamieson, C. Gaiddon, I. Ott, C. G. Hartinger

Inorg. Chem. 2018, 57, 14427-14434

6. Analysis of ruthenium anticancer agents by MEEKC‐UV and MEEKC–ICP‐MS: Impact of structural motifs on lipophilicity and biological activity

K. Giringer, H. U. Holtkamp, S. Movassaghi, W. D. J. Tremlett, N. Y. S. Lam, M. Kubanik, C. G. Hartinger

Electrophoresis 2018 39, 1201-1207

5. Challenges and discoveries in the total synthesis of complex polyketide natural products

I. Paterson*, N. Y. S. Lam*

J. Antibiot. 2018, 71, 215-233

4. Toward the total synthesis of patellazole B: synthesis of an advanced C1–C25 fragment corresponding to the macrocyclic skeleton

A. W. Phillips, M. J. Anketell, T. Balan, N. Y. S. Lam, S. Williams, I Paterson

Org. Biomol. Chem. 2018,16, 8286-8291

3. Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein–Ru (carbene) adduct

M. P Sullivan, M. K. Nieuwoudt, G. A. Bowmaker, N. Y. S. Lam, D. Truong, D. C. Goldstone, C. G. Hartinger

Chem. Commun. 2018, 54, 6120-6123

2. A synthesis-enabled relative stereochemical assignment of the C1–C28 region of hemicalide

B. Y. Han*, N. Y. S. Lam*, C. I. MacGregor, J. M. Goodman, I. Paterson

Chem. Commun. 2018, 54, 3247-3250

1. Quinoline-para-quinones and metals: coordination-assisted formation of quinoline-ortho-quinones

M. Kubanik, N. Y. S. Lam, H. U. Holtkamp, T. Söhnel, R. F. Anderson, S. M. F. Jamieson, C. G. Hartinger

Chem. Commun., 2018, 54, 992-995

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